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北京时间10月7日下午,2013年诺贝尔生理学或医学奖揭晓,科学家James Rothman,Thomas Sudhof,and Randy Shekman 因在细胞内囊泡运输上的研究成果而获得此奖。
官方网址:http://www.nobelprize.org/
The Nobel Prize in Physiology or Medicine 2013 was awarded jointly to James E. Rothman, Randy W. Schekman and Thomas C. Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".
三位科学家简介:
James E. Rothman于1950年出生于美国麻省Haverhill,1976年从哈佛医学院获得博士学位,曾在MIT做过博后。1978年他进入斯坦福大学,开始了对细胞囊泡的研究。他曾任职的研究机构还包括普林斯顿大学、纪念斯隆-凯特灵癌症研究所和哥伦比亚大学。2008年,他加入耶鲁大学,目前为该校教授和细胞生物学系主席。
James E. Rothman教授个人主页及实验室主页:
www.cellbiology.yale.edu/people/james_rothman.profile
medicine.yale.edu/cellbio/rothman/index.aspx
James E. Rothman教授近年来亮点研究论文一览(部分):
【1】eLife:“Stapled Golgi cisternae remain in place as cargo passes through the stack”
Gregory Lavieu,Hong Zheng,James E Rothman
elife.elifesciences.org/content/2/e00558
【2】Nature Protocols:“Fusion of single proteoliposomes with planar, cushioned bilayers in microfluidic flow cells”
Erdem Karatekin & James E Rothman
www.nature.com/nprot/journal/v7/n5/full/nprot.2012.019.html
【3】Nature Structural & Molecular Biology:“Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state”
Feng Li, Frédéric Pincet, Eric Perez, Claudio G Giraudo, David Tareste & James E Rothman
www.nature.com/nsmb/journal/v18/n8/full/nsmb.2102.html
【4】PNAS:“Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes”
Grégory Lavieua,Lelio Orcib, Lei Shia, Michael Geilingc, Mariella Ravazzolab, Felix Wielandc, Pierre Cossonb, and James E. Rothmana
www.pnas.org/content/107/15/6876.long
【5】PNAS:“A fast, single-vesicle fusion assay mimics physiological SNARE requirements”
Erdem Karatekina,b,1, Jérme Di Giovannic,d, Cécile Iborrac,d, Jeff Colemanb, Ben O'Shaughnessye, Michael Seagarc,d, and James E. Rothmanb
www.pnas.org/content/107/8/3517.long
【6】PNAS:“SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes”
David Tareste, Jingshi Shen, Thomas J. Melia, and James E. Rothman *
www.pnas.org/content/105/7/2380.long
【7】Science:“Membrane Fusion: Grappling with SNARE and SM Proteins”
Thomas C. Südhof1, James E. Rothman2